November 14, 2018
Meta-analysis suggests that testosterone treatment enhances mood in hypogonadal and eugonadal men.
Testosterone therapy (TT) moderately relieves depressive symptoms in hypogonadal and eugonadal men, according to researchers.
The Testosterone Trials and other recent studies indicated a potential mood-enhancing effect from TRT, so Andreas Walther, PhD, of the Universitt Dresden in Germany conducted an updated systematic review and meta-analysis including 27 randomized controlled trials (RCTs) published 2000 to March 2018 comparing TT with placebo. Some of the 1890 men included in the studies met the definition of hypogonadism (total testosterone 345.82 ng/dL or less), whereas others had normal testosterone levels.
TT users were 2.3 times more likely to experience reduction in depressive symptoms (variably defined) compared with placebo, according to results published in JAMA Psychiatry. TT doses greater than 500 mg per week were associated with greater symptom reduction. Purported effects did not vary by age. Acceptability of TT did not differ significantly from placebo.
Testosterone treatment appears to be effective and efficacious in reducing depressive symptoms in men, particularly when higher-dosage regimens were applied in carefully selected samples, Dr Walther and his collaborators concluded. They cautioned, however, that the body of ...